Hyperuricemia and hypoalbuminemia predispose to cisplatin-induced nephrotoxicity
β Scribed by Amin A. Nanji; David J. Stewart; Nadia Z. Mikhael
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 253 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
Key words: nephrotoxicity; cisplatin; radical scavengers; methimazole; rat In adult rats 6 mg kg -1 body wt. cisplatin given i.p. was nephrotoxic. Four days of i.p. treatment with 40 mg kg -1 body wt. methimazole, which started 1 day before CP, prevented increases in blood urea nitrogen and in the r
## Abstract Cisplatin is widely used in the treatment of human tumors, but it is a nephrotoxic drug. Early pragmatic clinical trials have shown that cisplatinβinduced renal toxicity is greatly reduced through the use of high hydration, a large NaCl supply and mannitol infusion, but the precise mech