Hypersensitivity to carboplatin in children

✍ Scribed by Schiavetti, Amalia; Varrasso, Giulia; Maurizi, Palma; Castello, Manuel A.

• Book ID: 101217567
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 49 KB
• Volume: 32
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/(sici)1096-911x(199903)32:3<183::aid-mpo4>3.0.co;2-p

✦ Synopsis

Background:

Hypersensitivity reactions are rare but at times severe complications to cytostatic drugs.

Procedure:

The percentage of allergic reactions to carboplatin and their clinical features were evaluated in 185 children affected by different solid tumors and treated with etoposide-carboplatin chemotherapy. allergic reactions that occurred during or immediately following etoposide infusion (5 cases, 2.8%) were excluded from the study.

Results:

Seventeen out of 185 patients (9.2%) suffered from allergic responses to carboplatin. the first of these occurred after an average of 10.1 courses (range, 1-23; median, 9). the risk calculated according to the number of courses is 2% at 6 courses, 11.3% at 12 courses, and 47% at more than 12 courses.

Conclusions:

The high risk of allergic reactions to multiple courses of carboplatin should be kept in mind when developing treatment regimens that include the drug.