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Hyperphosphorylation and cleavage of tau at the C-terminal enhance the secretion of tau

โœ Scribed by Mohamed, Nguyen-Vi; Plouffe, Vanessa; Rivest-McGraw, Jessica; Bertrand, Johanne; Lauzon, Michel; Leclerc, Nicole


Book ID
123353248
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
54 KB
Volume
8
Category
Article
ISSN
1552-5260

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Pathological changes in the microtubule associated protein tau, leading to tau-containing filamentous lesions, are a major hallmark common to many types of human neurodegenerative diseases, including Alzheimer's disease (AD). No structural data are available which could rationalize the extensive con