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Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein

โœ Scribed by Robert Porzig; David Singer; Ralf Hoffmann


Book ID
116294945
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
158 KB
Volume
358
Category
Article
ISSN
0006-291X

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Western blot analysis proved that all cluster-2 MAbs recognize identical or overlapping disulfide-bond-dependent epitopes, indicating the presence of a disulfide-bond-stabilized EGP-2 domain carrying highly immunodominant non-linear epitopes. The apparent immunodominance of this domain makes it diff