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Endogenous overproduction of β-amyloid induces tau hyperphosphorylation and decreases the solubility of tau in N2a cells

✍ Scribed by Y.-P. Wang; X.-C. Wang; Q. Tian; Y. Yang; Q. Zhang; J.-Y. Zhang; Y.-C. Zhang; Z.-F. Wang; Q. Wang; H. Li; J.-Z. Wang

Book ID
106207007
Publisher
Springer
Year
2006
Tongue
English
Weight
530 KB
Volume
113
Category
Article
ISSN
1435-1463

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## Abstract Reactive astrocytes surround amyloid depositions and degenerating neurons in Alzheimer's disease (AD). It has been previously shown that β‐amyloid peptide induces inflammatory‐like responses in astrocytes, leading to neuronal pathology. Reactive astrocytes up‐regulate nerve growth facto