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Hypermutable myotonic dystrophy CTG repeats in transgenic mice

✍ Scribed by Monckton, Darren G.; Coolbaugh, Mary I.; Ashizawa, Ken T.; Siciliano, Michael J.; Caskey, C. Thomas


Book ID
109915225
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
648 KB
Volume
15
Category
Article
ISSN
1061-4036

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Myotonic dystrophy (MD), an autosomal dominant multisystemic disorder with a high phenotypic variability, is the most common muscular dystrophy in adult life. The mutation underlying DM has been characterized as an expanded CTG trinucleotide repeat sequence in the 3 ' untranslated region of a protei