Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15Ink4b-deficient mice
β Scribed by Wolff, Linda; Garin, Matthew T; Koller, Richard; Bies, Juraj; Liao, Wei; Malumbres, Marcos; Tessarollo, Lino; Powell, Douglas; Perella, Christine
- Book ID
- 110068176
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 823 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
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In vitro and in vivo, myeloid leukemic and preleukemic cells exhibit variable sensitivity to the antiproliferative and proapoptotic effects induced already at low concentrations of DNA methyltransferase (DNMT) inhibitors. The molecular mechanisms underlying this variable sensitivity of leukemic blas
Inactivation of p15(Ink4b) expression by promoter hypermethylation occurs in up to 80% of acute myeloid leukemia (AML) cases and is particularly common in the FAB-M2 subtype of AML, which is characterized by the presence of the RUNX1-ETO translocation in 40% of cases. To establish whether the loss o