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Hypermethylation of the gene promoter and enhancer region can regulate Fas expression and sensitivity in colon carcinoma

✍ Scribed by Petak, I; Danam, R P; Tillman, D M; Vernes, R; Howell, S R; Berczi, L; Kopper, L; Brent, T P; Houghton, J A


Book ID
110016462
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
305 KB
Volume
10
Category
Article
ISSN
1350-9047

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Hypermethylation of the APC (adenomatous
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Germline mutations of the putative tumor suppressor gene APC are associated in high frequency with the familial adenomatous polyposis, predisposing the patients to colorectal neoplasia. Similarly, sequence analyses have revealed that in more than half of patients with sporadic colorectal carcinoma o