CpG hypermethylation of the promoter region inactivates the estrogen receptor-β gene in patients with prostate carcinoma
✍ Scribed by Dana Nojima; Long-Cheng Li; Abhipsa Dharia; Geetha Perinchery; Leopoldo Ribeiro-Filho; Tien-Sze B. Yen; Rajvir Dahiya
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 561 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0008-543X
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## Abstract The incidence and mortality of prostate cancer (PC) is approximately 2‐fold higher among African‐Americans as compared to Caucasians and very low in Asian. We hypothesize that inactivation of __GSTP1__ genes through CpG methylation plays a role in the pathogenesis of PC, and its ability
DNA hypermethylation of CpG-rich promoter sequences is associated with tumor suppressor gene inactivation in many human cancers, notably in carcinoma of the prostate and the urinary bladder. Recently, the mouse homologue of the tumor necrosis factor receptor superfamily 6 (TNFRSF6) gene was reported