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Hyperlipidemia stimulates the extracellular release of the nuclear high mobility group box 1 protein

✍ Scribed by Raluca Haraba; Viorel I. Suica; Elena Uyy; Luminita Ivan; Felicia Antohe


Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
350 KB
Volume
346
Category
Article
ISSN
0302-766X

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The box a domain of high mobility group
✍ Sanghyun Lee; Hojung Song; Hyun Ah Kim; Binna Oh; Dong Yun Lee; Minhyung Lee 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 445 KB

## Abstract High mobility group box‐1 (HMGB‐1) is a DNA binding nuclear protein and pro‐inflammatory cytokine. The box A domain of HMGB‐1 (rHMGB‐1A) exerts an anti‐inflammatory effect, inhibiting wild‐type HMGB‐1 (wtHMGB‐1). In this study, HMGB‐1A was evaluated as an siRNA carrier with anti‐inflamm