High mobility group box-1 recognition: The beginning of a RAGEless era?
✍ Scribed by Filipe Branco-Madeira; Bart N. Lambrecht
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 263 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1757-4676
No coin nor oath required. For personal study only.
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## Abstract High mobility group box‐1 (HMGB‐1) is a DNA binding nuclear protein and pro‐inflammatory cytokine. The box A domain of HMGB‐1 (rHMGB‐1A) exerts an anti‐inflammatory effect, inhibiting wild‐type HMGB‐1 (wtHMGB‐1). In this study, HMGB‐1A was evaluated as an siRNA carrier with anti‐inflamm
## Abstract High‐mobility group box–1 (HMGB1) was originally identified as a ubiquitously expressed, abundant nonhistone DNA‐binding protein. Recently, it was found to act as a cytokine‐like mediator of delayed endotoxin lethality and of acute lung injury. Previously, we reported that HMGB1 is mass
High mobility group box 1 protein (HMGB1), a cytokine actively secreted by phagocytes and passively released from necrotic cells, is an inflammatory mediator in experimental hepatic ischemia/reperfusion injury. We characterized its expression in human liver transplantation. In 20 patients, in additi