𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Hyperglycaemia due to insulin resistance caused by interferon-γ

✍ Scribed by Shiba, T.; Higashi, N.; Nishimura, Y.

Book ID
101217869
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
30 KB
Volume
15
Category
Article
ISSN
0742-3071

No coin nor oath required. For personal study only.

✦ Synopsis

Marked hyperglycaemia (30.9 mmol l -1 ) during interferon-␥ (IFN-␥) therapy for asymptomatic recurrent renal cancer as multiple lung metastases in a 52-year-old man is described. Although the involvement of IFN-␥ has been reported in the development of autoimmune diabetes, in this case, antibodies against pancreatic ␤-cells including anti-islet cell antibody (ICA) and anti-glutamic acid decarboxylase (GAD) antibody were negative. Moreover, serum level of immunoreactive insulin (IRI) (11 U ml -1 at fasting) and urinary excretion of C-peptide (108 g day -1 , reference range: 20-130) suggested insulin resistance, supported by results of insulin tolerance tests. With insulin therapy and cessation of IFN-␥, fasting blood glucose concentration returned to 6.2 mmol l -1 , and insulin therapy was discontinued. The injection of IFN-␥ may cause hyperglycaemia because of insulin resistance, rather than ␤-cell injury.

📜 SIMILAR VOLUMES

Resistance to a non-immunogenic tumor, i
Resistance to a non-immunogenic tumor, induced by Corynebacterium parvum or Listeria monocytogenes, is abrogated by anti-interferonγ
✍ Robert Keller; Ruth Keist; Thomas P. Leist; Peter H. Van Der Meide 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 378 KB

The complex processes that determine the outcome of the interaction of tumor and host were explored in the operationally simple and reproducible rat D-I 2 ascites tumor model. Animals exhibit weak spontaneous resistance against this tumor that is not augmented by repeated inoculation, by various rou

Modulating the metastatic potential of m
Modulating the metastatic potential of murine raw117 large-cell lymphoma cells by selection for resistance to interferon-γ
✍ Ronald A. Labiche; Garth L. Nicolson 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 919 KB

Highly metastatic, in vivo-selected cells of RAW I 17-H I0 large-cell lymphoma have been shown to be more resistant than poorly metastatic parental RAW I 17-P cells to the cytolytic and cytostatic activities of activated macrophages in co-culture experiments. Activated macrophages are known to produ