Modulating the metastatic potential of murine raw117 large-cell lymphoma cells by selection for resistance to interferon-γ

✍ Scribed by Ronald A. Labiche; Garth L. Nicolson

• Book ID: 102868889
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: French
• Weight: 919 KB
• Volume: 54
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910540624

✦ Synopsis

Highly metastatic, in vivo-selected cells of RAW I 17-H I0 large-cell lymphoma have been shown to be more resistant than poorly metastatic parental RAW I 17-P cells to the cytolytic and cytostatic activities of activated macrophages in co-culture experiments. Activated macrophages are known to produce soluble, cytostatic respiration-inhibiting factors, and such activities can be duplicated by interferon-gamma (IFN-y) or by combinations of I F N y and Escherichio coli lipopolysaccharide (LPS). Highly metastatic RAW I 17-H I0 cells are more resistant to the cytostatic effects of IFN-y and LPS than poorly metastatic