Resistance to a non-immunogenic tumor, induced by Corynebacterium parvum or Listeria monocytogenes, is abrogated by anti-interferonγ
✍ Scribed by Robert Keller; Ruth Keist; Thomas P. Leist; Peter H. Van Der Meide
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- French
- Weight
- 378 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
The complex processes that determine the outcome of the interaction of tumor and host were explored in the operationally simple and reproducible rat D-I 2 ascites tumor model. Animals exhibit weak spontaneous resistance against this tumor that is not augmented by repeated inoculation, by various routes, of irradiated syngeneic D-I 2 tumor cells, but considerably enhanced after local administration of heatkilled Corynebacteriurn parvurn (CP) or Listeria rnonocytogenes (LM) organisms. Inoculation of conventional or monoclonal anti-rat IFNy antibodies into the same compartment did not affect spontaneous tumor resistance, but largely abrogated the tumor-protective effect triggered by CP or LM.
Our findings support the concept that IFNy, produced by T cells in the course of the specific immune response raised against immunogenic micro-organisms, is able to enhance and to maintain local tumor resistance and thus to strengthen the capacity of the host to cope with a non-immunogenic tumor.