## Abstract The __AML1__ gene (also known as __RUNX1__) at 21q22 codes for core binding factor (CBF) α, which forms a heterodimer with CBF β that acts as a transcriptional activating factor. CBF is a critical regulator in the generation and differentiation of definitive hematopoietic stem cells and
Hypereosinophilia with a low blast count as the initial manifestation of acute myeloid leukaemia with RUNX1-RUNX1T1
✍ Scribed by Georg Stussi; André Tichelli; Urs Schanz; Jeroen Goede
- Book ID
- 108676280
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 188 KB
- Volume
- 146
- Category
- Article
- ISSN
- 0007-1048
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## Abstract The translocation t(16;21) involving __RUNX1__ (__AML1__) and resulting in the __RUNX1‐CBFA2T3__ fusion is a rare but recurrent abnormality mostly found in therapy‐related acute myeloid leukemia (t‐AML) associated with agents targeting topoisomerase II (topo II). We characterized, at th
## Abstract __RUNX1__ (previously __AML1__) is involved in multiple recurrent chromosomal rearrangements in hematological malignances. Recently, we identified a novel fusion between __RUNX1__ and __LPXN__ from an acute myeloid leukemia (AML) patient with t(11;21)(q12;q22). This translocation genera