## Abstract The __AML1__ gene (also known as __RUNX1__) at 21q22 codes for core binding factor (CBF) ฮฑ, which forms a heterodimer with CBF ฮฒ that acts as a transcriptional activating factor. CBF is a critical regulator in the generation and differentiation of definitive hematopoietic stem cells and
โฆ LIBER โฆ
Fusion of AML1/Runx1 to Copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation
โ Scribed by Ramsey, H; Zhang, Do-E; Richkind, K; Burcoglu-O'Ral, A; Hromas, R
- Book ID
- 110055580
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 90 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0887-6924
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
PRDX4, a member of the peroxiredoxin fam
โ
Yanming Zhang; Neelmini Emmanuel; Ginny Kamboj; Jianjun Chen; Muhammad Shurafa;
๐
Article
๐
2004
๐
John Wiley and Sons
๐
English
โ 210 KB
๐ 1 views
LPXN, a member of the paxillin superfami
โ
Hai-Ping Dai; Yong-Quan Xue; Jian-Wei Zhou; Ai-Ping Li; Ya-Fang Wu; Jin-Lan Pan;
๐
Article
๐
2009
๐
John Wiley and Sons
๐
English
โ 342 KB
๐ 1 views
## Abstract __RUNX1__ (previously __AML1__) is involved in multiple recurrent chromosomal rearrangements in hematological malignances. Recently, we identified a novel fusion between __RUNX1__ and __LPXN__ from an acute myeloid leukemia (AML) patient with t(11;21)(q12;q22). This translocation genera