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A novel and cytogenetically cryptic t(7;21)(p22;q22) in acute myeloid leukemia results in fusion of RUNX1 with the ubiquitin-specific protease gene USP42

✍ Scribed by Paulsson, K; Békássy, A N; Olofsson, T; Mitelman, F; Johansson, B; Panagopoulos, I

Book ID
110056597
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
158 KB
Volume
20
Category
Article
ISSN
0887-6924

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The ETV6 gene is a member of the ETS family of transcription factors and the main target of chromosomal rearrangements affecting chromosome band 12p13. To date, more than 15 fusion partners of ETV6 have been characterized at the molecular level. Most of these fusions encode chimeric proteins with on