Hydroxyamides versus amino alcohols in the enantioselective addition of diethylzinc to benzaldehyde
✍ Scribed by Tomás de las Casas Engel; Beatriz Lora Maroto; Antonio García Martínez; Santiago de la Moya Cerero
- Book ID
- 108284374
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 193 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0957-4166
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📜 SIMILAR VOLUMES
Optically active ferrocenyl amino alcohols have been prepared from commercially available l-alaninol and l-leucinol. They have been used in catalytic amounts as chiral ligands in the addition of diethylzinc to benzaldehyde. 1-Phenylpropanol has thus been obtained in up to 95% enantiomeric excess.
The reaction of diethylzinc with benzaldehyde catalyzed by a small amount of chiral 2-amino-l-alcohols in toluene at room temperature gave optically active 1-phenylpropan-l-01 almost quantitatively in 2 50% ee. Asymmetric alkylation of various aldehydes with organometallic reagents in the presence
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