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Chiral ferrocenyl amino alcohols as analogues of norephedrine catalysts for enantioselective addition of diethylzinc to benzaldehyde

✍ Scribed by Stéphanie Bastin; Jacques Brocard; Lydie Pélinski

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
146 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

Optically active ferrocenyl amino alcohols have been prepared from commercially available l-alaninol and l-leucinol. They have been used in catalytic amounts as chiral ligands in the addition of diethylzinc to benzaldehyde. 1-Phenylpropanol has thus been obtained in up to 95% enantiomeric excess.

📜 SIMILAR VOLUMES

ChemInform Abstract: Chiral Ferrocenyl A
ChemInform Abstract: Chiral Ferrocenyl Amino Alcohols as Analogues of Norephedrine Catalysts for Enantioselective Addition of Diethylzinc to Benzaldehyde.
✍ Stephanie Bastin; Jacques Brocard; Lydie Pelinski 📂 Article 📅 2000 🏛 John Wiley and Sons ⚖ 28 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Chiral ferrocenyl amino alcohols for ena
Chiral ferrocenyl amino alcohols for enantioselective additions of diethylzinc to aldehydes
✍ Stéphanie Bastin; Mihaela Ginj; Jacques Brocard; Lydie Pélinski; Guy Novogrocki 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 262 KB

Optically active ferrocenyl amino alcohols have been prepared from commercially available L-alaninol, L-leucinol and L-valinol. They have been utilized as chiral ligands in the catalytic addition of diethylzinc to aldehydes. The influence of the substituents on the stereogenic centers of the ligand

Enantioselective addition of diethylzinc
Enantioselective addition of diethylzinc to benzaldehyde catalyzed by a small amount of chiral 2-amino-1-alcohols
✍ Nobuki Oguni; Takao Omi 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 103 KB

The reaction of diethylzinc with benzaldehyde catalyzed by a small amount of chiral 2-amino-l-alcohols in toluene at room temperature gave optically active 1-phenylpropan-l-01 almost quantitatively in 2 50% ee. Asymmetric alkylation of various aldehydes with organometallic reagents in the presence