✦ LIBER ✦

Enantioselective addition of diethylzinc to benzaldehyde catalyzed by a small amount of chiral 2-amino-1-alcohols

✍ Scribed by Nobuki Oguni; Takao Omi

Publisher: Elsevier Science
Year: 1984
Tongue: French
Weight: 103 KB
Volume: 25
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)81300-9

No coin nor oath required. For personal study only.

✦ Synopsis

The reaction of diethylzinc with benzaldehyde catalyzed by a small amount of chiral 2-amino-l-alcohols in toluene at room temperature gave optically active 1-phenylpropan-l-01 almost quantitatively in 2 50% ee.

Asymmetric alkylation of various aldehydes with organometallic reagents in the presence of chiral organic reagents has been recently developed and high ee was attained in some cases'.

In order to attain high optical yield in the reported systems, the use of a stoichiometric amount of chiral reagents and to run the reaction at very low temperature of -llOe-120°C are essential.

Very recently we reported that chiral catalysis by transition metal complexes of d-camphorquinonedioxime in the reaction of diethylzinc with arylaldehydes gave optically active alcohols almost quantitatively in 40 -60% ee at room temperature2. The reaction was based

📜 SIMILAR VOLUMES

Highly enantioselective addition of diet

Highly enantioselective addition of diethylzinc to aldehydes catalyzed by chiral s-amino-t-alcohols

✍ Kenso Soai; Masami Watanabe; Atsuhiro Yamamoto; Takeshi Yamashita 📂 Article 📅 1991 🏛 Elsevier Science ⚖ 335 KB

Enantioselective conjugate addition of d

Enantioselective conjugate addition of diethylzinc to chalcone catalyzed by Co(acac)2 and chiral amino alcohols

✍ AndréH.M. de Vries; Ben L. Feringa 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 135 KB

Co(acac) 2 in the presence of chiral ligands has been employed as catalyst for the enantioselective conjugate addition of diethylzinc to chalcone. With chiral amino alcohols derived from (+)-camphor, enantioselectivities up to 83% were achieved.

Chiral ferrocenyl amino alcohols as anal

Chiral ferrocenyl amino alcohols as analogues of norephedrine catalysts for enantioselective addition of diethylzinc to benzaldehyde

✍ Stéphanie Bastin; Jacques Brocard; Lydie Pélinski 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 146 KB

Optically active ferrocenyl amino alcohols have been prepared from commercially available l-alaninol and l-leucinol. They have been used in catalytic amounts as chiral ligands in the addition of diethylzinc to benzaldehyde. 1-Phenylpropanol has thus been obtained in up to 95% enantiomeric excess.

Enantioselective Conjugate Addition of D

Enantioselective Conjugate Addition of Diethylzinc to Chalcone Catalyzed by Ni(acac)2 and Chiral β-Amino Alcohols

✍ Wang Heng-Shan; Wang Rui; Da Chao-Shan; Xin Zhuo-Qun; Su Wu; Xiao Yi-Nan; Liu Da 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 263 KB 👁 1 views

ChemInform Abstract: Enantioselective Co

ChemInform Abstract: Enantioselective Conjugate Addition of Diethylzinc to Chalcone Catalyzed by Co(acac)2 and Chiral Amino Alcohols.

✍ A. H. M. DE VRIES; B. L. FERINGA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

ChemInform Abstract: Chiral Ferrocenyl A

ChemInform Abstract: Chiral Ferrocenyl Amino Alcohols as Analogues of Norephedrine Catalysts for Enantioselective Addition of Diethylzinc to Benzaldehyde.

✍ Stephanie Bastin; Jacques Brocard; Lydie Pelinski 📂 Article 📅 2000 🏛 John Wiley and Sons ⚖ 28 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v