Enantioselective conjugate addition of diethylzinc to chalcone catalyzed by Co(acac)2 and chiral amino alcohols
✍ Scribed by AndréH.M. de Vries; Ben L. Feringa
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 135 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0957-4166
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✦ Synopsis
Co(acac)
2 in the presence of chiral ligands has been employed as catalyst for the enantioselective conjugate addition of diethylzinc to chalcone. With chiral amino alcohols derived from (+)-camphor, enantioselectivities up to 83% were achieved.
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Abstracti Conjugate addition of diethylzinc to chalcones is catalysed by complexes prepared in situ from Ni(acac), and cb-era-N,N-dialkyl-3-aminoisoborneols or (+)-ci.r-endo-N,N-dimethyl-3aminoborneol ((+)-DAB) (13b). The products are obtained with enantioselectivities up to 84 %. When scalemic (-)-
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