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Enantioselective conjugate addition of diethylzinc to chalcone catalyzed by Co(acac)2 and chiral amino alcohols

✍ Scribed by AndréH.M. de Vries; Ben L. Feringa


Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
135 KB
Volume
8
Category
Article
ISSN
0957-4166

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✦ Synopsis


Co(acac)

2 in the presence of chiral ligands has been employed as catalyst for the enantioselective conjugate addition of diethylzinc to chalcone. With chiral amino alcohols derived from (+)-camphor, enantioselectivities up to 83% were achieved.


📜 SIMILAR VOLUMES


Enantioselective conjugate addition of d
✍ André H.M. de Vries; Johan F.G.A. Jansen; Ben L. Feringa 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 994 KB

Abstracti Conjugate addition of diethylzinc to chalcones is catalysed by complexes prepared in situ from Ni(acac), and cb-era-N,N-dialkyl-3-aminoisoborneols or (+)-ci.r-endo-N,N-dimethyl-3aminoborneol ((+)-DAB) (13b). The products are obtained with enantioselectivities up to 84 %. When scalemic (-)-

Enantioselective addition of diethylzinc
✍ Nobuki Oguni; Takao Omi 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 103 KB

The reaction of diethylzinc with benzaldehyde catalyzed by a small amount of chiral 2-amino-l-alcohols in toluene at room temperature gave optically active 1-phenylpropan-l-01 almost quantitatively in 2 50% ee. Asymmetric alkylation of various aldehydes with organometallic reagents in the presence