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Enantioselective conjugate addition of diethylzinc to chalcones catalysed by chiral Ni(II) aminoalcohol complexes

✍ Scribed by André H.M. de Vries; Johan F.G.A. Jansen; Ben L. Feringa

Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
994 KB
Volume
50
Category
Article
ISSN
0040-4020

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✦ Synopsis

Abstracti Conjugate addition of diethylzinc to chalcones is catalysed by complexes prepared in situ from Ni(acac), and cb-era-N,N-dialkyl-3-aminoisoborneols or (+)-ci.r-endo-N,N-dimethyl-3aminoborneol ((+)-DAB) (13b). The products are obtained with enantioselectivities up to 84 %. When scalemic (-)-ci.r-era-N,,Ndimethyl-3aminoisoborneol ((-)-DAIB) (3~) was employed in the reaction a positive nonlinear relationship was found. Several factors which govern catalyst activity and enantioselectivity have been investigated.

📜 SIMILAR VOLUMES

Enantioselective conjugate addition of d
Enantioselective conjugate addition of diethylzinc to chalcone catalyzed by Co(acac)2 and chiral amino alcohols
✍ AndréH.M. de Vries; Ben L. Feringa 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 135 KB

Co(acac) 2 in the presence of chiral ligands has been employed as catalyst for the enantioselective conjugate addition of diethylzinc to chalcone. With chiral amino alcohols derived from (+)-camphor, enantioselectivities up to 83% were achieved.

Enantioselective addition of diethylzinc
Enantioselective addition of diethylzinc to aldehydes catalysed by polymer supported chiral oxazaborolidine
✍ N. El Moualij; C. Caze 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 522 KB

Two new polymers containing chiral oxazaborolidines as pendant groups have been prepared by chemical modification of crosslinked 2-vinylthiophene copolymers. The polymers are used as chiral auxiliaries in the catalysis of asymmetric addition of diethylzinc to aldehydes. We found that when these new