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Hydrophobic interactions between the 5-alkyl group of 2,4-diamino-6-methylpyrimidines and dihydrofolate reductase

โœ Scribed by Ho, Yiu K.; Zakrzewski, Sigmund F.; Mead, Lawrence H.


Book ID
126323736
Publisher
American Chemical Society
Year
1973
Tongue
English
Weight
358 KB
Volume
12
Category
Article
ISSN
0006-2960

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A novel series of dihydrofolate reductase inhibitors was uncovered during an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and their biological activity was evaluated. These new analogs do not possess an oxygen at the 4 position and contain a monocyclic pyrimidine ring.