✦ LIBER ✦

Inhibitors of dihydrofolate reductase: Design, synthesis and antimicrobial activities of 2,4-diamino-6-methyl-5-ethynylpyrimidines

✍ Scribed by Michael L. Jones; David P. Baccanari; Robert L. Tansik; Christine M. Boytos; Sharon K. Rudolph; Lee F. Kuyper

Publisher: Journal of Heterocyclic Chemistry
Year: 1999
Tongue: English
Weight: 313 KB
Volume: 36
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570360122

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: Inhibitors of Dihyd

ChemInform Abstract: Inhibitors of Dihydrofolate Reductase: Design, Synthesis and Antimicrobial Activities of 2,4-Diamino-6-methyl-5-ethynylpyrimidines.

✍ Michael L. Jones; David P. Baccanari; Robert L. Tansik; Christine M. Boytos; Sha 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

Design, synthesis and biological evaluat

Design, synthesis and biological evaluation of 2,4-diamino-6-methyl-5-substitutedpyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors

✍ Aleem Gangjee; Hiteshkumar D. Jain; Sherry F. Queener 📂 Article 📅 2005 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 75 KB

Nine novel nonclassical 2,4-diamino-6-methyl-5-thioarylsubstituted-7H-pyrrolo [2,3-d]pyrimidines 2-10 were synthesized as potential inhibitors of dihydrofolate reductase and as antitumor agents. The analogues contain various electron donating and electron withdrawing substituents on the phenylsulfan

Design, Synthesis and Biological Evaluat

Design, Synthesis and Biological Evaluation of 2,4-Diamino-6-methyl-5-substituted-pyrrolo[2,3-d]pyrimidines as Dihydrofolate Reductase Inhibitors.

✍ Aleem Gangjee; Hiteshkumar D. Jain; Sherry F. Queener 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 21 KB 👁 2 views

ChemInform Abstract: Selective Pneumocys

ChemInform Abstract: Selective Pneumocystis carinii Dihydrofolate Reductase Inhibitors: Design, Synthesis, and Biological Evaluation of New 2,4-Diamino-5-substituted-furo[2,3-d]pyrimidines.

✍ A. GANGJEE; X. GUO; S. F. QUEENER; V. CODY; N. GALITSKY; J. R. LUFT; W. PANGBORN 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

2,4-diamino-6-substituted-5- (4-carbetho

2,4-diamino-6-substituted-5- (4-carbethoxyphenylazo) pyrimidines as irreversible inhibitors of folic acid reductase

✍ J. Hampshire; P. Hebborn; A. M. Triggle; D. J. Triggle 📂 Article 📅 1966 🏛 John Wiley and Sons 🌐 English ⚖ 191 KB

ChemInform Abstract: Nonclassical 2,4-Di

ChemInform Abstract: Nonclassical 2,4-Diamino-5-aryl-6-ethylpyrimidine Antifolates: Activity as Inhibitors of Dihydrofolate Reductase from Pneumocystis carinii and Toxoplasma gondii and as Antitumor Agents.

✍ C. ROBSON; M. A. MEEK; J.-D. GRUNWALDT; P. A. LAMBERT; S. F. QUEENER; D. SCHMIDT 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

Nonclassical 2,4-Diamino-5-aryl-6-ethylpyrimidine Antifolates: Activity as Inhibitors of Dihydrofolate Reductase from Pneumocystis carinii and Toxoplasma gondii and as Antitumor Agents. -Title compounds such as (I) exhibit potent inhibitory activity against dihydrofolate reductase (DHFR) from Toxop