Hydrolysis of oligodeoxynucleotide phosphodiester linkages
β Scribed by Hebai Shen; Jingfen Xia; Haifeng Yang; Yumei Luo
- Book ID
- 105639994
- Publisher
- SP Science China Press
- Year
- 2001
- Tongue
- English
- Weight
- 129 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1674-7291
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A new way of constructing anomeric glycosyl phosphodiester linkages has been explored. Non-anomeric monosaccharide hydrogen phosphonate monoesters (5 and 9) have been used as acceptors in couplings using various benzylated galactosyl donors (trichloroacetimidate, thioglycoside, bromo and chloro sug
## Abstract A comprehensive study of the base hydrolysis of all phosphodiester bondβcontaining capsular polysaccharides of the 23βvalent pneumococcal vaccine is described here. Capsular polysaccharides from serotypes 6B, 10A, 17F, 19A, 19F, and 20 contain a phosphodiester bond that connects the rep