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Hydrogen Peroxide-Induced Injury of Cells and Its Prevention by Inhibitors of Poly(ADP-Ribose) Polymerase

✍ Scribed by Ingrid U. Schraufstatter, Paul A. Hyslop, Daniel B. Hinshaw, Roger G. Spragg, Larry A. Sklar and Charles G. Cochrane

Book ID
123632932
Publisher
National Academy of Sciences
Year
1986
Tongue
English
Weight
882 KB
Volume
83
Category
Article
ISSN
0027-8424

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Effect of a poly(ADP-ribose) polymerase
Effect of a poly(ADP-ribose) polymerase inhibitor on DNA breakage and cytotoxicity induced by hydrogen peroxide and Ξ³-radiation
✍ LuΓ­sa CristΓ³vΓ£o; JosΓ© Rueff πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 695 KB

The activity of poly(ADP-ribose) polymerase (PARP) is activated upon recognition of DNA strand breaks by its DNA-binding domain and the stimulation of this nuclear enzyme seems to be an early response of cells exposed to a variety of different DNA-damaging agents. In the present work we evaluate the