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Pneumonia-Induced Sepsis and Gut Injury: Effects of a Poly-(ADP-Ribose) Polymerase Inhibitor

✍ Scribed by Suzana M. Lobo; Susana R. Perez Orrico; Márcio M. Queiroz; Geni S. Cunrath; Gisela S.A. Chibeni; Ligia M. Contrin; Patricia M. Cury; Emanuel de Almeida Burdmann; Antonia M. de Oliveira Machado; Paulo Togni; Daniel De Backer; Jean-Charles Preiser; Czaba Szabó; Jean-Louis Vincent


Book ID
116701903
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
206 KB
Volume
129
Category
Article
ISSN
0022-4804

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Effect of a poly(ADP-ribose) polymerase
✍ Luísa Cristóvão; José Rueff 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 695 KB

The activity of poly(ADP-ribose) polymerase (PARP) is activated upon recognition of DNA strand breaks by its DNA-binding domain and the stimulation of this nuclear enzyme seems to be an early response of cells exposed to a variety of different DNA-damaging agents. In the present work we evaluate the