Crystalline hydrates of hydrolytically susceptible pharmaceuticals are commonly encountered, and are particularly prevalent in the b-lactam class of antibiotics. In order to rationalize how the apparent chemical incompatibility between water and b-lactams is reduced through crystallization, a review
Hydrates and Solid-State Reactivity: β-Lactam Antibiotics
✍ Scribed by Magali B. Hickey; Matthew L. Peterson; Eric S. Manas; Juan Alvarez; Fredrik Haeffner; Orn Almarsson
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 11 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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reevaluation of beta-lactam bond deformation as a criterion for a penicillin-like mode-of-action. ## 11. MECHANISM OF ACTION The mechanism of action of the naturally-occurring monobactams was examined at an early They were shown to interact with certain of the penicillin-binding proteins (PBP's) o
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