𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Hybridization properties and nuclease resistance of oligo(2′-O-tetrahydropyranylribonucleotides)

✍ Scribed by M. A. Kuznetsova; D. V. Pyshnyi; M. N. Repkova; A. G. Venyaminova

Book ID
110669222
Publisher
SP MAIK Nauka/Interperiodica
Year
2000
Tongue
English
Weight
318 KB
Volume
26
Category
Article
ISSN
1068-1620

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis, hybridization, and nuclease r
Synthesis, hybridization, and nuclease resistance properties of 2′-O-aminooxyethyl (2′-O-AOE) modified oligonucleotides
✍ Andrew M. Kawasaki; Martin D. Casper; Thazha P. Prakash; Sheri Manalili; Henri S 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 221 KB

The novel RNA mimic 2'-O-AOE has been incorporated into antisense oligonucleotides. This 2'-O-modification significantly enhances hybridization against target RNA, and furthermore, exhibits specificity for RNA over DNA. The nuclease resistance (SVPD) of 2'-O-AOE modified phosphodiester oligonucleoti

Synthesis of 2′-O-[2-[(N,N-dialkylamino)
Synthesis of 2′-O-[2-[(N,N-dialkylamino)oxy]ethyl]-modified oligonucleotides: hybridization affinity, resistance to nuclease, and protein binding characteristics
✍ Thazha P Prakash; Andrew M Kawasaki; Elena A Lesnik; Namir Sioufi; Muthiah Manoh 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 226 KB

Synthesis of a series of 2 0 -O-[2-[(N,N-dialkylamino)oxy]ethyl]-modified 5-methyluridine nucleoside phosphoramidites and solid supports are described. Using these monomers, modified oligonucleotides containing phosphodiester linkages were synthesized in high yields. These modified oligonucleotides