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Synthesis and hybridization properties of 2′-O-methylated oligoribonucleotides incorporating 2′-O-naphthyluridines

✍ Scribed by Sekine, Mitsuo ;Oeda, Yusuke ;Iijima, Yoshihiro ;Taguchi, Haruhiko ;Ohkubo, Akihiro ;Seio, Kohji


Book ID
118198273
Publisher
Royal Society of Chemistry
Year
2011
Tongue
English
Weight
686 KB
Volume
9
Category
Article
ISSN
1477-0520

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2′-O-Propargyl oligoribonucleotides: Syn
✍ Morten Grøtli; Mark Douglas; Ramon Eritja; Brian S. Sproat 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 850 KB

Fully modified oligonucleotide sequences containing 2'-O-propargylribonucleotides were synthesised on automated DNA-synthesisers using the phosphoramidite approach. A highly selective alkylation procedure was used to introduce the propargyl functionality, thereby enabling the synthesis of protected