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Huntingtin–protein interactions and the pathogenesis of Huntington's disease

✍ Scribed by Shi-Hua Li; Xiao-Jiang Li

Book ID
113932487
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
844 KB
Volume
20
Category
Article
ISSN
0168-9525

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## Abstract Huntington's disease is one of the several neurodegenerative diseases caused by dominant mutations that expand the number of glutamine codons within an existing poly‐glutamine (polyQ) repeat sequence of a gene. An expanded polyQ sequence in the huntingtin gene is known to cause the hunt