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Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment

✍ Scribed by J.L.C.M Dorne; K Walton; A.G Renwick

Book ID
117450088
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
375 KB
Volume
41
Category
Article
ISSN
0278-6915

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We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants. Good correlations were observed between the intrinsic clearance (CL int ) for 4-hydroxylation and CYP3A4 content and between the CL int for a