Human T-Cell Leukemia Virus Type I (HTLV-I) and Blood Transfusion
β Scribed by LARSON, CAROL J.; TASWELL, HOWARD F.
- Book ID
- 123130819
- Publisher
- Mayo Clinic
- Year
- 1988
- Tongue
- English
- Weight
- 931 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0025-6196
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## Abstract In order to clarify the cellular tropism of human Tβcell leukemia virus type I (HTLVβI) and the effects of HTLVβI infection on Tβcell functions, we investigated the infectiousness of HTLVβI on T cells bearing Tβcell receptor (TCR) Ξ³Ξ΄ and functional alterations of the HTLVβIβinfected TCR
HTLV-I propagated in lMR9O human diploid fibroblasts was transmitted to human myeloid leukemia HL60 cells at a low efficiency. After co-cultivation for 3 months, the viral genome was detected in 14/48 HL60 cell clones. Among the 14 HTLV-I-infected clones, 8 contained subgenomic fragments alone or in