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Handbook of Proteolytic Enzymes || Human T-cell Leukemia Virus Type I (HTLV-I) Retropepsin

✍ Scribed by Nguyen, Jeffrey-Tri

Book ID
120074336
Publisher
Elsevier
Year
2013
Weight
390 KB
Category
Article
ISBN
012382219X

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## Abstract In order to clarify the cellular tropism of human T‐cell leukemia virus type I (HTLV‐I) and the effects of HTLV‐I infection on T‐cell functions, we investigated the infectiousness of HTLV‐I on T cells bearing T‐cell receptor (TCR) Ξ³Ξ΄ and functional alterations of the HTLV‐I‐infected TCR

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HTLV-I propagated in lMR9O human diploid fibroblasts was transmitted to human myeloid leukemia HL60 cells at a low efficiency. After co-cultivation for 3 months, the viral genome was detected in 14/48 HL60 cell clones. Among the 14 HTLV-I-infected clones, 8 contained subgenomic fragments alone or in