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Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

✍ Scribed by Leigh Zawel; Jia Le Dai; Phillip Buckhaults; Shibin Zhou; Kenneth W Kinzler; Bert Vogelstein; Scott E Kern

Book ID: 117736051
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 192 KB
Volume: 1
Category: Article
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(00)80061-1

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## Abstract Transforming growth factor‐β (TGF‐β) signaling is known to depend on the formation of Smad2/3‐Smad4 transcription regulatory complexes. However, the signaling functions of Smad2/3‐Smad4 during TGF‐β‐induced responses are obscure as TGF‐β also initiates a number of other signaling pathwa