Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription
β Scribed by Ross, Sarah; Cheung, Edwin; Petrakis, Thodoris G; Howell, Michael; Kraus, W Lee; Hill, Caroline S
- Book ID
- 110031714
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 645 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0261-4189
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## Abstract The testisβspecific linker histone H1t is transcribed exclusively in pachytene spermatocytes during spermatogenesis. The H1t promoter contains two imperfect inverted repeats which together comprise the Xβbox motif that is known to bind the transcription factor regulatory factor X (RFX).
## Abstract Transcription of the mammalian testisβspecific linker histone __H1t__ gene occurs only in pachytene primary spermatocytes during spermatogenesis. Studies of the wild type (Wt) and mutant H1t promoters in transgenic mice show that transcription of the __H1t__ gene is dependent upon the T