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Human salivary proline-rich (Pr) proteins: A posttranslational derivation of the phenotypes

✍ Scribed by Robert C. Karn; Robert D. Friedman; A. Donald Merritt

Publisher
Springer
Year
1979
Tongue
English
Weight
856 KB
Volume
17
Category
Article
ISSN
0006-2928

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✦ Synopsis

The acidic proline-rich proteins ( Pr) showing genetic polymorphism were purified from human parotid salivas by gel filtration and ion exchange chromatography. Molecular weight determinations, amino acid composition analyses, and polypeplide mapping experiments indicate that the Pr 3 protein is a fragment qfl the Pr 1 protein. Studies of a parotid saliva factor capable of converting Pr 1 to Pr 3 and Pr 2 to Pr 4 indicate that Pr 3 and Pr 4 are generated from Pr 1 and Pr 2, respectively. Evidence suggests that the converting.factor is a protease capable o J" posttranslationally cleaving Pr 1 and Pr 2, the primary or derived products of alleles Pr I and Pr 2.

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