Genetic polymorphism of human salivary proline-rich proteins: Further genetic analysis

✍ Scribed by Edwin A. Azen; Carter L. Denniston

• Publisher: Springer
• Year: 1974
• Tongue: English
• Weight: 576 KB
• Volume: 12
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00487820

✦ Synopsis

Electrophoresis of concentrated parotid saliva on slab polyacrylamide gels negatively stained with 3,3'-dimethoxybenzidine and hydrogen peroxide (DMB stain) showed nine phenotypes among the proline-rieh proteins. These phenotypes are the expression of four autosomal codominant alleles. Gene frequencies are, ['or Caucasians, Pr I = 0.640, Pr I' = 0.005, Pr 2 = 0.080, Pr 2' = 0.275; for Negroes, Pr ~ = 0.700, Pr 1' = 0.050, Pr 2 = 0.080, Pr 2' = O.170;for Chinese, Pr 1 = 0.770, Pr 1' = 0, Pr z = 0, Pr 2' = 0.230. The presence or absence of another pair of proteins giving the same negative staining is inherited as an autosomal dominant trait (Db). Homozygous Db + + and heterozygous Db +individuals could not be distinguished. The genetic determinant (Db) for this pair of proteins is either closely linked to or part of the Pr locus. Gene frequencies are, for Caucasians, Db + = 0.12, Db-= 0.88;for Negroes, Db + = 0.56, Db-= 0.44;for Chinese, Db + = 0.07, Db-= 0.93.