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Human papillomavirus 25-related DNA in solitary keratoacanthoma

✍ Scribed by A. Gassenmaier; H. Pfister; O. P. Hornstein

Publisher: Springer-Verlag
Year: 1986
Tongue: English
Weight: 790 KB
Volume: 279
Category: Article
ISSN: 0340-3696
DOI: 10.1007/bf00417525

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✦ Synopsis

Solitary keratoacanthomas of 32 patients were screened for the presence of human papillomavirus (HPV) 25 DNA, which was originally isolated and molecularly cloned from warts of an epidermodysplasia verruciformis (Ev) patient. Biotinylated virus DNA was hybridized in situ to thin sections obtained from paraffin-embedded material. HPV DNA was detected in 12 of 32 tumors under stringent conditions, and in 2 additional tumors under relaxed conditions.

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