Our study aimed at evaluating the presence of human papillomavirus (HPV) DNA in a series of 84 paraffinembedded (PET) penile carcinomas. We have also investigated the presence of p53 mutations in these tumors by immunohistochemistry (IHC), single-stranded conformational polymorphism (SSCP) and DNA s
Human papillomavirus DNA sequences in penile carcinomas in Brazil
β Scribed by Luisa Lina Villa; Ademar Lopes
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- French
- Weight
- 401 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
β¦ Synopsis
To detect the presence of human papillomavirus (HPV) DNA in penile cancers, 18 squamous-cell carcinomas were studied by Southern blot analysis. All specimens were from Brazilian patients ranging in age from 31 to 78 years. Of these, 7 harbored DNA sequence homology. Most positive specimens contained more than 100 copies of viral DNA. No HPV 16 was detected in our samples. Presence of HPV DNA sequences in the samples studied was not correlated with the patients' age or race, nor with extent or progress of disease.
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