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Presence of episomal and integrated human papillomavirus DNA sequences in cervical carcinoma

✍ Scribed by Dr. Kong-Bung Choo; Chao-Chih Pan; Ming-Sun Liu; Shou-Hwa Han; Heung-Tat Ng; Cyre-Ping Chen; Yi-Nan Lee; Chung-Faye Chao; Ching-Leung Meng; Ming-Yang Yeh

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
497 KB
Volume
21
Category
Article
ISSN
0146-6615

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✦ Synopsis

Thirty surgical samples of squamous cell carcinoma of the cervix obtained from Chinese women were analysed for the presence of human papillomavirus (HPV) types 16 and 18 using Southern blot hybridization procedure. HPV16 was detected in 53% while HPV18 was found in only 6% of the samples analyzed. When compared with other reports, variation in the geographic distribution of these two HPV types in association with cervical carcinoma is noted. Thirty-seven and a half percent of the HPV16-positive samples contained this HPV type in episomal form and an equal number in cellular DNA-integrated form. The simultaneous presence of both episomal and integrated forms was found in the remaining 25% of the positive samples. The two HPV18-positive cases harbored only episomal viral genome and were not superinfected by HPV16. Analysis of the HPV16 integration samples showed that single integration events had probably occurred and some of the viral sequences had been lost on or subsequent to integration.

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