Human papillomavirus-5b DNA integrated in a metastatic tumor: cloning, nucleotide sequence and genomic organization
✍ Scribed by Yoshiro Yabe; Akiko Sakai; Takako Hitsumoto; Hiroko Hanafusa; Yoshimi Jitsumori; Hajime Ogura
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- French
- Weight
- 41 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
FIGURE 2 -Nucleotide sequence and genomic organization of the viral DNA integrated within a metastatic tumor. (a) Nucleotide sequence of the cellular DNA fragment cloned from a metastatic tumor. Nucleotides between 2 SphI (GCATGC) sites (Fig. 1) are numbered above from 1 (G on the 5Ј end) to 8852 (C on the 3Ј end). (b) Nucleotide sequence of HPV-5b genome, with positions indicated below as in Yabe et al. (1991). The nucleotides between positions 1383 and 4697 of the cellular DNA are all identical (indicated below by asterisks) with those between positions 6111 and 1646 of the HPV-5b genome: of this identical sequence, only the 10 nucleotides on both ends and the 6 in the middle are shown. (c) Genomic regions of HPV-5b existing in the integrated viral segment. NC, non-coding region.