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Human papillomavirus type-16-related DNA in genital Bowen's disease and in bowenoid papulosis

✍ Scribed by Hans Ikenberg; Lutz Gissmann; Gerd Gross; Elke-Ingrid Grussendorf-Conen; Harald Zur Hausen

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
436 KB
Volume
32
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

^32^P‐labelled DNA of HPV 16 which has been isolated and molecularly cloned from a cervical carcinoma (DΓΌrst et al., 1983) was used to screen the cellular DNAs obtained from 20 different biopsies of Morbus Bowen or Bowenoid papulosis, respectively, by Southern blot analysis. Under conditions of differing stringency for the hybridization, HPV 16 DNA or related sequences were identified in 6 out of 10 cases of Morbus Bowen (4 out of 5 from a genital localization) and in 8 out of 10 biopsies from Bowenoid papulosis. One additional case of the latter disease contained DNA sequences of an HPV type not yet classified. There is evidence for the presence of another HPV DNA in two of the HPV‐16‐positive tumors. A large number of normal genital tissue samples were negative for HPV DNA.

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