Human Molecular Genetics, Fourth Edition

✍ Scribed by Tom Strachan, Andrew Read

• Publisher: Garland Science
• Year: 2010
• Tongue: English
• Leaves: 704
• Edition: 4th
• Category: Library

✦ Synopsis

Human Molecular Genetics is an established and class-proven textbook for upper-level undergraduates and graduate students which provides an authoritative and integrated approach to the molecular aspects of human genetics. While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject. The text has been restructured so genomic technologies are integrated throughout, and next generation sequencing is included. Genetic testing, screening, approaches to therapy, personalized medicine, and disease models have been brought together in one section. Coverage of cell biology including stem cells and cell therapy, studying gene function and structure, comparative genomics, model organisms, noncoding RNAs and their functions, and epigenetics have all been expanded.

✦ Table of Contents

Contens
......Page 2
Ch. 01 -
Nucleic Acid Structure and Gene Expression......Page 17
Ch. 02 - Chromosome Structure and Function
......Page 44
Ch. 03 - Genes in Pedigrees and Populations
......Page 75
Ch. 04 - Cells and Cell-Cell Communication......Page 104
Ch. 05 - Principles of Development......Page 145
Ch. 06 - Amplifying DNA: Cell-based DNA Cloning and PCR
......Page 174
Ch. 07 - Nucleic Acid Hybridization:
Principles and Applications
......Page 201
Ch. 08 - Analyzing the Structure and Expression of Genes and Genomes
......Page 222
Ch. 09 - Organization of the Human Genome......Page 263
Ch. 10 - Model Organisms, Comparative Genomics, and Evolution
......Page 303
Ch. 11 - Human Gene Expression
......Page 349
Ch. 12 - Studying Gene Function
in the Post-Genome Era
......Page 384
Ch. 13 - Human Genetic Variability and Its Consequences......Page 407
Ch. 14 - Genetic Mapping of Mendelian Characters
......Page 441
Ch. 15 - Mapping Genes Conferring Susceptibility to Complex Diseases
......Page 465
Ch. 16 - Identifying Human Disease Genes and Susceptibility Factors
......Page 494
Ch. 17 - Cancer Genetics
......Page 533
Ch.18 - Genetic Testing of Individuals
......Page 564
Ch. 19 - Pharmacogenetics, Personalized Medicine, and Population Screening
......Page 599
Ch. 20 - Genetic Manipulation of Animals for Modeling Disease and Investigating Gene Function
......Page 631
Ch. 21 - Genetic Approaches to Treating Disease
......Page 665