Human Gene Evolution (Human Molecular Genetics S.)

✍ Scribed by David Cooper

• Publisher: Garland Science
• Year: 1999
• Tongue: English
• Leaves: 509
• Category: Library

✦ Synopsis

The story of our evolutionary past is told in our genome sequence. Human Gene Evolution deals with the origins of human genes, describes their structure, function, organisation and expression. The text integrates our emerging knowledge of chromosome and genome structure, and discusses the nature of the mutational mechanisms underlying evolutionary change.

✦ Table of Contents

Contents......Page 6
Preface......Page 12
Acknowledgements......Page 15
Abbreviations......Page 16
Websites cited in the text......Page 17
PART 1 INTRODUCTION AND OVERVIEW......Page 20
Structure and function in the human genome......Page 22
Evolution of the human genome......Page 74
PART 2 EVOLUTION OF GENE STRUCTURE......Page 124
Introns, exons, and evolution......Page 126
Genes and gene families......Page 158
Promoters and transcription factors......Page 240
Pseudogenes and their formation......Page 284
PART 3 MUTATIONAL MECHANISMS IN EVOLUTION......Page 314
Single base-pair substitutions......Page 316
Contractions and expansions in gene size and number......Page 348
Gross gene rearrangements......Page 408
Molecular reconstruction of ancient genes/ proteins......Page 442
Index to Human Gene Symbols used in text......Page 458
Index......Page 494