This work provides guidance on the principles underlying modern human molecular genetics. This new edition has been updated to take account of the changes in our understanding of this field since the late 1990s. DNA structure and gene expression -- Chromosome structure and function -- Cells and development -- Genes in pedigrees and populations -- Amplifying DNA : PCR and cell-based DNA cloning -- Nucleic acid hybridization : principles and applications -- Analyzing DNA and gene structure, variation and expression -- Genome projects and model organisms -- Organization of the human genome -- Human gene expression -- Instability of the human genome : mutation and DNA repair -- Our place in the tree of life -- Genetic mapping of Mendelian characters -- Identifying human disease genes -- Mapping and identifying genes conferring susceptibility to complex diseases -- Molecular pathology -- Cancer genetics -- Genetic testing in individuals and populations -- Beyond the genome project : functional genomics, proteomics and bioinformatics -- Genetic manipulations of cells and animals -- New approaches to treating disease