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Human intestinal microvascular endothelial cells express CXCR4 and its sole ligand stromal cell-derived factor-1: Regulation of human intestinal mucosal angiogenesis

✍ Scribed by Heidemann, Jan; Ogawa, Hitoshi; Rafiee, Parvaneh; Maaser, Christian; Gockel, Henning R.; Domschke, Wolfram; Binion, David G.; Dwinell, Michael B.


Book ID
122072535
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
263 KB
Volume
124
Category
Article
ISSN
0016-5085

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Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine produced by stromal cells that acts as a chemoattractant for human CD34 + progenitor cells. We investigated the expression of CXCR4, the receptor for SDF-1, on CD34 + cells from different hematopoietic sites and developmental stages. CXCR4 was