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Human Interleukin-10 Gene Transfer Is Protective in a Rat Model of Parkinson's Disease

โœ Scribed by Johnston, Louisa C; Su, Xiaomin; Maguire-Zeiss, Kathleen; Horovitz, Karen; Ankoudinova, Irina; Guschin, Dmitry; Hadaczek, Piotr; Federoff, Howard J; Bankiewicz, Krystof; Forsayeth, John


Book ID
118119099
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
397 KB
Volume
16
Category
Article
ISSN
1525-0016

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## Abstract A typical feature of Parkinson's disease is the progressive loss of dopaminergic neurons in the substantia nigra, in which inhibition of mitochondrial complex I activity may play an important role. Rotenone or 1โ€methylโ€4โ€phenylโ€1,2,3,6โ€tetrahydropyridine (MPTP) inhibit the mitochondrial