✦ LIBER ✦

Human exposure to styrene

✍ Scribed by D. Bauer; M. Guillem

Publisher: Springer-Verlag
Year: 1976
Tongue: English
Weight: 410 KB
Volume: 37
Category: Article
ISSN: 0340-0131
DOI: 10.1007/bf00409363

No coin nor oath required. For personal study only.

✦ Synopsis

The derivatization of phenylglyoxylic acid (PGA), a urinary styrene metabolite, gives with diazomethane under ordinary reaction conditions secondary products as expected from the behaviour of other -keto acids Thus reproducible quantitative analysis becomes difficult It is shown that by proper selection of reaction conditions (low temperature, short reaction time) these secondary transformations can be inhibited and exclusive derivatization to the methylester is obtained A quantitative determination of urinary PGA can be based on this derivatization procedure However, this method is not considered suitable for routine monitoring due to the delicate reaction conditions necessary The results are discussed with reference to a recently published procedure based on an unknown derivative of PGA.

📜 SIMILAR VOLUMES

Human exposure to styrene

✍ M. Guillemin; D. Bauer 📂 Article 📅 1976 🏛 Springer-Verlag 🌐 English ⚖ 328 KB

A simple and specific method for the quantitative gaschromatographic (GC) analysis of mandelic and phenylglyoxylic acid (MA and PGA), human urinary styrene metabolites, is described MA is determined by trimethylsilylation and subsequent GC analysis Because of difficulties involved in the direct dete

Human styrene exposure

✍ Pierre O. Droz; Michel P. Guillemin 📂 Article 📅 1983 🏛 Springer-Verlag 🌐 English ⚖ 885 KB

Evaluation of low exposure to styrene

✍ H. Wieczorek; J. K. Piotrowski 📂 Article 📅 1985 🏛 Springer-Verlag 🌐 English ⚖ 681 KB

Volunteers (six men and one woman) were exposed by inhalation to styrene within the concentration range of 20 to 200 mg/m 3 The average retention of styrene vapours in the respiratory tract was 71 % The yield of styrene metabolism measured within 24 h was 39 and 17 % for mandelic acid and phenylglyo

Evaluation of low exposure to styrene

✍ H. Wieczorek 📂 Article 📅 1985 🏛 Springer-Verlag 🌐 English ⚖ 219 KB

Four volunteers were exposed dermally to styrene vapours within the concentration range of 1300 to 3200 mg/m 3 The increase in the levels of mandelic and phenylglyoxylic acids in urine after exposure was strongly noticeable The dermal vapour absorption coefficient (a) was calculated: for styrene it

Cumulative exposure to styrene and visua

Cumulative exposure to styrene and visual functions

✍ Laura Castillo; Mary Baldwin; Marie-Pascale Sassine; Donna Mergler 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 177 KB

Human exposure to aluminum

✍ Seymour G. Epstein 📂 Article 📅 1990 🏛 Springer Netherlands 🌐 English ⚖ 614 KB