HPLC DETERMINATION OF VALPROIC ACID IN PLASMA BY CONJUGATION TO A HYDRAZIDE
β Scribed by Darlington, Daniel N. ;Gonzales, Mary D.
- Book ID
- 126840911
- Publisher
- Taylor and Francis Group
- Year
- 2013
- Tongue
- English
- Weight
- 415 KB
- Volume
- 36
- Category
- Article
- ISSN
- 1082-6076
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π SIMILAR VOLUMES
A sensitive and specific method for the determination of valproic acid in plasma has been developed. After the proteins in the plasma have been precipitated with a saturated solution of ammonium sulfate in 1 N HCI, the valproic acid, together with the internal standard, is extracted from the plasma
## Abstract A rapid capillary zone electrophoresis method with indirect UV detection was developed and validated for the determination of valproic acid (VPA) in human plasma. The analyses were carried out under optimized conditions, using a buffer system composed of 15Β mM benzoate and 0.5Β mM cetylt